16^th International Conference on Structural and Molecular Biology October 12-13, 2021 Manila, Philippines

Structural Biology is that the branch of biology which embarks the importance of biophysics and biochemistry within the molecular structure of biological macromolecules. It also provides information about the effect of structural alterations of macromolecules on their function. This process of determination of structures of proteins, nucleic acids may take years because the shape, size and assemblies of those molecules could also be altering the function.

Molecular biology concerns the molecular basis of biological activity between the various systems of a cell, including the interactions between the different types of DNA, RNA and proteins and their biosynthesis, and studies how these interactions are regulated. It has many applications like in gene finding, molecular mechanisms of diseases and its therapeutic approaches by cloning, expression, and regulation of gene. Research area includes gene expression, epigenetics and chromatin structure and function, RNA processing, functions of non-coding RNAs, transcription. Nowadays, most advanced research are going on these topics: Molecular biology, DNA replication, repair and recombination, Transcription, RNA processing, Post-translational modification, proteomics, Mutation, Site-directed mutagenesis, Epigenetics, chromatin structure and function, Molecular mechanisms of diseases.

Biochemistry is that the study of chemical processes happening inside the physical body. Recently this subject has found its importance within the biological world because it has found its importance altogether fields of bioscience and biology. By controlling information flow through biochemical signaling and therefore the flow of energy through metabolism, biochemical processes produce to the complexity of life. Its main focus is to know how biological molecules produce to the processes that occur within living cells.

Biophysics is that the trending topic within the field of biology. It relates physics and biology. In other words, it signifies how traditional physical methods are wont to study the biological phenomena inside the physical body. Biophysical research shares significant overlap with biochemistry, biology, chemistry, physiology, nanotechnology, bioengineering, computational biology, biomechanics, and systems biology.

Computational approaches are a boon for structural biology. These methods use the concepts of bioinformatics to work out the structure of macromolecules. generally, the structure of molecules is decided by experimental methods is both time intense and price effective. to beat these constraints, computational approaches like ab-initio modelling, homology modelling and threading method are used.

Molecular modelling involves the hypothetical and computational procedures which are wont to mimic the behavior of macromolecules. Molecular modelling techniques are utilized in various fields a number of which are drug design, computational chemistry, materials science and computational biology. These methods are used for studying and understanding the properties of the molecules. one among the main applications of molecular modelling is molecular simulation. this is often the technique which uses powerful lculatiocomputers to simulate the interactions between atoms and to know the properties of materials. Such simulations involve methods that range from very detailed quantum mechanical cans on atoms to coarse-grained classical dynamics of huge groups of molecules on a timescale of milliseconds or longer.

Molecular dynamics (MD) deals with the study of physical movements of the atoms and molecules using simulation method, so it's mentioned together of the sort of N-body simulation. The atoms and molecules are allowed to interact for a hard and fast period of your time, giving a view of the dynamic evolution of the system. The trajectories of atoms and molecules are commonly determined by solving them numerically using Newton’s equations of motion for a gaggle of collaborating particles. The forces between the particles and their potential energies are calculated using inter-atomic potentials or molecular mechanics force fields. Steered molecular dynamics (SMD)

A biomarker is an attribute which will be studied as an indicator of pathogenic and biological operation alongside pharmacological retort to a therapeutic involvement. They indicate either normal or diseased activity within the body. Biomarkers are specific molecules, genes, gene products, hormones, cells, or enzymes.

Drug designing is an ingenious process to seek out new medication centered on the knowledge of biological target. Drug is most ordinarily a little molecule that inhibits or activates the function of a biomolecule, which successively outcomes during a therapeutic benefit to the patient. Drug design commonly but not essentially relies on computational techniques. this sort of modelling is usually mentioned to as computer-aided drug design.

Signaling is that the process through which the cells communicate with one another. they are often secreted from the cell and released into the extracellular space. Regulation of organic phenomenon comprises a comprehensive range of mechanisms that are employed by cells to manage the assembly of specific gene products and is familiarly termed as gene regulation. Sophisticated programs of organic phenomenon are extensively observed in biology, for instance to trigger developmental pathways, adapt to new food sources, or answer environmental stimuli.

Sequence analysis are often explained as a process of exposing DNA, RNA or peptide sequence to a good range of analytical methods so as to know its structure, function and evolution. The methods include sequence alignment and biological databases. Synergistic use of three-dimensional structures and deep sequencing is completed to understand the effect of personalized medicine. The usage of sequence analysis in structural biology will pave the thanks to new methods which may be utilized to work out the structure of molecules.