16^th International Conference on Structural & Molecular Biology June 27-28, 2022 Taipei, Taiwan

Track 1: Structural Biology and the Evolution of Bio macromolecules

Structural biology is a branch of molecular biology, biochemistry, and biophysics concerned with the molecular structure of biological macromolecules (especially proteins, made up of amino acids, RNA or DNA, made up of nucleotides, and membranes, made up of lipids), how they acquire the structures they have, and how alterations in their structures affect their function.

Track 2: DNA & RNA

Both DNA and RNA are made from nucleotides, each containing a five-carbon sugar backbone, a phosphate group, and a nitrogen base. DNA provides the code for the cell's activities, while RNA converts that code into proteins to carry out cellular functions.

Track 3: Proteomics

Proteomics is the analysis of the entire protein complement of a cell, tissue, or organism under a specific, defined set of conditions. In its present state, it is dependent on decades of technological and instrumental developments. The field of proteomics is particularly important because most diseases are manifested at the level of protein activity.

Track4: Genomics

Genomics is the study of all of a person's genes (the genome), including interactions of those genes with each other and with the person's environment. Genomics, the study of genes, is making it possible to predict, diagnose, and treat diseases more precisely and personally than ever. A complete human genome contains three billion base pairs of DNA, uniquely arranged to give us our fundamental anatomy and individual characteristics such as height and hair color.

Track 5: Computational Approaches in Structural Biology

Computational Biology includes most of the aspects bioinformatics. It is the science of using biological data to develop algorithms or models to understand among various biological systems and relationships. There are approximately more than 3.3 million sequences without structure. This gap in the https://structuralbiology.biochemistryconferences.com/structural knowledge can be bridged by computation. Computational biology has become an important part of developing emerging technologies for the field of biology. Identification of suitable template of the related protein family plays a major role. Computational structural biology or structural bioinformatics is concerned with the analysis, simulation and prediction of the structure, dynamics and interactions of large biomolecules such as proteins, DNA and RNA. Such systems push the limits of our understanding and the limits of computing power.

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Track 6: Signaling Biology

In biology, cell signaling is the ability of a cell to receive, process, and transmit signals with its environment and with itself. Cell signaling is a fundamental property of all cellular life in prokaryotes and eukaryotes. Cells consist of proteins called receptors which bind to signaling molecule. They in turn initiate a physiological response and also it governs the cellular activities and coordination. It controls gene expression which is vital for cells to function properly. Also, cell signaling network helps to understand how it responds to the environment.

Track7: Drug Designing and Biomarkers

Drug designing is an inventive process of finding new medication based on the target knowledge. A drug is commonly a small compound which produces a therapeutic effect. There are different methods of drug designing. Designing a drug based on the three-dimensional structure and computational techniques are known as structure-based drug design and computer aided drug design respectively. There are various stages involved in computer aided drug design such as hit identification, hit to lead optimization and lead optimization. In structure-based drug design, the structure is obtained either through x-ray crystallography or NMR spectroscopy. Ligand-based drug design depends on the knowledge of molecules that bind to the biological target of our interest. Correlation between calculated and theoretical can be derived and this QSAR relationship is used to derive analogs. Biomarkers include tools and technologies that aid in dynamic and powerful approach to understand the spectrum of neurological diseases in knowing the prediction, cause, diagnosis, progression, regression, or outcome of treatment of a disease.

Track 8: Advances in Structural and Molecular Biology

Structural biology is the oldest of all biological disciplines and is still an expanding field. The main goal of structural biology is to achieve a complete understanding about the cellular structure in relation to the molecular mechanisms involved in the cellular processes. New insights are currently emerging into the macromolecular structures which involves in the signal transduction. It encompasses a full range of relationship from tissues to molecules. Structural biology has a very broad range and is highly diversified. There have been several major advances in molecular biology in the past few years. New technologies either improve existing techniques or develop new approaches to old questions to generate information more quickly, easily, accurately or in a more easily repeatable fashion than existing method.

Track 9: Structural Biology in Cancer Therapeutics

The major part of research is being carried out in the area of cancer. Cancer is defined as the abnormal growth of cells. There are numerous types of cancer that affects people of all age. All gene banks have the responsibilities of acquiring the most important plant materials for their region without undue duplication; successfully treating and storing samples; maintaining and regenerating the collection without losing or changing genetic material (e.g. by mixing or mislabeling seed samples combines with molecular biology to design novel drugs mainly to cure cancer. The biologists carry out research in order to understand the biomolecules, identify different drug targets and improvise cancer therapies.

Track 10: BLOTTING TECHNIQUES

Blotting is used in molecular biology for the identification of proteins and nucleic acids and is widely used for diagnostic purposes. This technique immobilizes the molecule of interest on a support, which is a nitro cellulosic membrane or nylon. Following gel electrophoresis, probes are often used to detect specific molecules from the mixture. However, probes cannot be applied directly to the gel.

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Track 11: DNA fingerprinting

DNA fingerprinting is a laboratory technique used to establish a link between biological evidence and a suspect in a criminal investigation. A DNA sample taken from a crime scene is compared with a DNA sample from a suspect. If the two DNA profiles are a match, then the evidence came from that suspect.

Track 12: PCR

Polymerase chain reaction (PCR) is a method widely used to rapidly make millions to billions of copies (complete or partial) of a specific DNA sample, allowing scientists to take a very small sample of DNA and amplify it. PCR is fundamental to many of the procedures used in genetic testing and research, including analysis of ancient samples of DNA and identification of infectious agents. Using PCR, copies of very small amounts of DNA sequences are exponentially amplified in a series of cycles of temperature changes.

Track 13: Hybrid Approaches for Structure Prediction

Structural bioinformatics is a highly cost-efficient solution for accelerated determination of the three-dimensional structures of proteins. Purely computational prediction methods, such as advanced fold recognition, composite approaches, ab initio fragment assembly, and molecular docking are routinely applied today. Hybrid method combines information from a varied set of experimental and computational sources. Hybrid approaches helps to overcome these limitations by incorporating limited experimental measurements, reliable structural models can be computed and unlikely predictions eliminated. Hybrid approaches take advantage of data derived from a range of very different biochemical and biophysical methods.

Track 14: VECTORS

In molecular cloning, a vector is a DNA molecule used as a vehicle to artificially carry foreign genetic material into another cell, where it can be replicated and/or expressed (e.g., plasmid, cosmid, Lambda phages). A vector containing foreign DNA is termed recombinant DNA. a vector is an organism that does not cause disease itself but which spreads infection by conveying pathogens from one host to another. Species of mosquito, for example, serve as vectors for the deadly disease Malaria.

Track 15: BIOINFORMATICS

Bioinformatics is defined as the application of tools of computation and analysis to the capture and interpretation of biological data. It is an interdisciplinary field, which harnesses computer science, mathematics, physics, and biology. it is used to identify correlations between gene sequences and diseases, to predict protein structures from amino acid sequences, to aid in the design of novel drugs, and to tailor treatments to individual patients based on their DNA sequences.

Track 16: GENE BANKS

Gene banks are a type of biorepository that preserves genetic material. For plants, this is done by in vitro storage, freezing cuttings from the plant, or stocking the seeds. All gene banks have the responsibilities of acquiring the most important plant materials for their region without undue duplication; successfully treating and storing samples; maintaining and regenerating the collection without losing or changing genetic material (e.g. by mixing or mislabeling seed samples.

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Market analysis:

This analysis forecast the Global Biochemistry Analyzers market to grow at a CAGR of 4.50 percent over the period 2016-2021. The focused region of Biochemistry Analyzer industry market includes North American, Europe and Asia etc., and the main country includes United States, Germany, Japan and China etc. North America is the leading region in Biochemical Analyzers following it is the European market is the second largest market for Biochemistry Analyzers.  The constant healthcare sector improvements and gigantic population base represented by the Asia Pacific region is expected to drive the importance in Asia Pacific Biochemical Analyzers market. The Biochemistry Analyzers market offers a healthy contribution in the In-Vitro Diagnostic market and is expected to grow in the upcoming years. The global market for in vitro diagnostics (IVD) products was $57.3 billion in 2014. The market is expected to grow from $60.3 billion in 2015 to $81.1 billion by 2021 at a compound annual growth rate (CAGR) of 6.1%. The North America leads the global IVD products market throughout the period, worth $24.6 billion in 2014. The market is expected to reach $29.4 billion in 2020 from $25.3 billion in 2015 increasing at a CAGR of 3.1%. The Asia is the fastest growing region of global IVD market with a CAGR of 12.9% from 2015 to 2021. The market is worth $15.3 billion in 2015 and is expected to reach $28.2 billion by 2021.

The graph below shows the changes in spending proportions projected to occur, in Biochemistry and Molecular-Biology market:

Molecular Biology Market:

The global Molecular Biology market size was valued at USD 5.77 billion in 2016 and is expected to witness a CAGR of 19.0% during the forecast period. Increase in research activities by end users has been one of the key factors responsible for the surge in demand for molecular biology enzymes, kits, and reagents.

The global isothermal nucleic acid technology (INAAT) market is estimated to reach $1,651 million by 2018 at a CAGR of 13.5% during the forecast period. The market growth is primarily attributed to increasing demand for advanced isothermal based molecular testing over conventional thermal polymerase chain reaction (PCR) technology.

Molecular Biology companies:

• Agilent Technologies, Inc.
• Bio-Rad Laboratories, Inc.
• Danaher Corporation
• Ge Healthcare Lifesciences
• Illumina, Inc.
• Life Technologies Corporation
• Promega Corporation
• Qiagen
• Roche Applied Science
• Sigma-Aldrich Co. Llc
• Takara Bio, Inc.
• Thermo Fischer Scientific, Inc.

The rising prevalence of genetic disorders is anticipated to propel the molecular diagnostics market. Molecular biology enzymes, kits, and reagents are used in Polymerase Chain Reaction (PCR) and epigenetics in molecular diagnostics. The market is further propelled by an increased incidence of genetic disorders amongst the geriatric population.

U.S. Molecular Biology Enzymes and kits & reagents market by product, 2014 - 2025 ($ billion)

Technological advancements in molecular biology enzymes, kits, and reagents are one of the factors contributing to growth. Manufacturers continuously develop advanced products with an objective to increase their share. These advanced products aim to ease research processes by offering enhanced efficiency and higher precision. For instance, in June 2015, Thermo Fisher Scientific, Inc. (U.S.) launched the new SMART Digest Kit, which was designed for biopharmaceutical and proteomic applications. The kit was designed to generate high-quality data with a significantly reduced sample preparation time compared to traditional in-solution digestion methods.

Increasing investments by pharmaceutical & biotechnology companies in research activities increased the availability of funds for academic & research institutions, and provisions of reimbursement for molecular diagnostics are other significant factors propelling growth.

Genetic information of an individual is highly confidential, hence cannot be shared. Genome sequencing aids in the identification and treatment of various diseases & disorders. Globally, there are no effective tools to secure the genetic information of an individual. Genetic information is accessible to doctors and insurance companies. This information is stored in a cloud database and can be used by researchers across the globe. Thus, lack of high-end technology to store genetic information is likely to restrain growth in the coming years.

Global molecular biology enzymes and kits & reagents market by application, 2016 (%)

The sequencing application segment is estimated to grow at the fastest rate during the forecast period. In the recent years, hospitals in developed or developing countries are implementing sequencing-based medical treatment. Furthermore, sequencing is also being used in cancer diagnosis, therapy, and treatment in collaboration with bioinformatics. In addition, the decreasing cost of sequencing is expected to increase the demand for sequencing during the forecast period.

Epigenetics is used during drug development and discovery process of cancer drugs. In the recent years, many countries across the globe are witnessing growth in the biopharmaceutical and biotechnology industry. For instance, according to the India Brand Equity Foundation, the biopharmaceutical industry in India was worth USD 11 million in 2016 and is estimated to reach USD 11.6 billion by 2017.

Synthetic biology is a new method wherein engineering principles are combined with biology to make new biological products. The growth of the synthetic biology market can be attributed to decreasing cost of DNA sequencing and increasing demand for vaccines, drugs, genetically modified crops, & biofuels.

Top Societies & Associations Associated with Bio Chemistry Research

Across the world:

• The American Society for Biochemistry and Molecular Biology
• European Federation for Clinical Chemistry and Laboratory Medicine
• Japan Society of Clinical Chemistry (JSCC)
• Australian Society Biochemistry and Molecular Biology
• Asia-Pacific Federation for Clinical Biochemistry and Laboratory Medicine(APFCB)
• Belgian Society of Biochemistry and Molecular Biology
• International Federation of Clinical Chemistry and Laboratory Medicine
• Spanish Society for Clinical Biochemistry and Molecular Pathology.