12th International Conference on STRUCTURAL AND MOLECULAR BIOLOGY
Technion-Israel Institute of Technology, Israel
Title: Targeting the Intracellular Proteome with T cell Mimicking antibodies; Structural and Functional Properties.
Biography: Yoram Reiter
We have created a unique class of human monoclonal antibodies that mimic the ability of the T cell receptor to recognize intracellular antigens in the context of the major histocompatibility complex (MHC). This approach harnesses the power of the cellular arm of the immune system to attack diseased cells with soluble, readily made human monoclonal antibodies. Distinct from conventional monoclonal approaches that only attack cell surface-associated proteins; this approach of generating T cell receptor-like antibodies now addresses the far more abundant intracellular proteome. The combination of these features opens entirely new vistas for the treatment of many kinds of diseases in oncology, autoimmunity and inflammation. The molecular properties of this unique family of molecules as well as the structure-function relationships studies will be presented considering their binding specificity properties.