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12th International Conference on STRUCTURAL AND MOLECULAR BIOLOGY

Osaka, Japan

Wei Li

Wei Li

Shantou University Medical College, China


Wei Li has his expertise and passion in fundamental biological and medical research, particular in areas related to three-dimensional structures of biologically relevant macromolecules and experimental data-driven molecular dynamics (MD) simulation and molecular docking and modeling. After years of wet- and dry-lab experience in research (including solution-state NMR, python programming and high-performance computer usage), he has developed a set of skills to uncover novel structural/functional insights through computational analysis of experimentally determined structures of biological molecules. Here, as an example in spinal muscular atrophy-related studies, his work presented the first attempt to link clinically identified SMA-linked mutations of SMN1 to the structural/functional deficiency of SMN, the protein that is critical to this neuromuscular disease.



Abstract : Title: How do SMA-linked mutations of SMN1 lead to structural/functional deficiency of the SMA protein?