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Wei Li


Wei Li

Shantou University Medical College, China

Biography

Wei Li has his expertise and passion in fundamental biological and medical research, particular in areas related to three-dimensional structures of biologically relevant macromolecules and experimental data-driven molecular dynamics (MD) simulation and molecular docking and modeling. After years of wet- and dry-lab experience in research (including solution-state NMR, python programming and high-performance computer usage), he has developed a set of skills to uncover novel structural/functional insights through computational analysis of experimentally determined structures of biological molecules. Here, as an example in spinal muscular atrophy-related studies, his work presented the first attempt to link clinically identified SMA-linked mutations of SMN1 to the structural/functional deficiency of SMN, the protein that is critical to this neuromuscular disease.

 

Abstract

Abstract : Title: How do SMA-linked mutations of SMN1 lead to structural/functional deficiency of the SMA protein?