Computational Approaches in Structural Biology

Computational Biology includes most of the aspects bioinformatics. It is the science of using biological data to develop algorithms or models to understand among various biological systems and relationships. There are approximately more than 3.3 million sequences without structure. This gap in the structural knowledge can be bridged by computation. Computational biology has become an important part of developing emerging technologies for the field of biology. Identification of suitable template of the related protein family plays a major role. The most common approaches in computational biology are ab-initio modelinghomology modeling and threading method. Among these approaches, genetic algorithm is found to be a promising co-operative computational method to solve the structure problem in reasonable time.

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