Structural Biology and Single Molecules

Single-molecule studies may be contrasted with measurements on an ensemble or bulk collection of molecules, where the individual behavior of molecules cannot be distinguished and only average characteristics can be measured. To study the individual biomolecules, biophysical methods have been developed. Thus it enables the biologist to monitor all the biological process and helps in understanding the underlying mechanism. Further, removal of ensemble average and fluctuations catalytic properties can be elucidated. Advancements like applying force on the biomolecules helps to obtain important information like how proteins couples function to structure. Thus with a clearer understanding of the individual components that comprise integrated living systems, researchers are better able to grasp the many complex interactions between gene products or molecules that cause disease.

  • Single Molecule Biophysics
  • Folding
  • Channels and Transporters
  • Enzyme Catalysis

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