Structural & Molecular Biology

Structural Virology

Viruses are small self-replicating organisms. Even though individually viruses are simple, as a group they are exceptionally diverse in both replication strategies and structures. To study the life cycle of human virus, we use various technologies like X-ray crystallography, cryo-electron microscopy. We investigate macromolecular interactions associated with virus cell entry, genome replication, assembly, and maturation. Viruses are very simple enough that we can aspire to understand their biology at a molecular level. Our efforts are directed towards using structural information for the development of anti-viral drugs and vaccines.